RAF Typhoon FGR4s have conducted a mission with French aircraft in a joint strike targeting an underground arms cache in Syrian territory operated by the IS group, as stated by the British defence ministry.
The location, located using intelligence, was assessed as containing munitions and bombs, the release indicated, and was situated in mountains just above Palmyra in Syria's central region.
"The RAF jets used laser-guided Paveway IV weapons to target a series of access tunnels providing entry to the facility... initial indications indicate the target was engaged successfully," the ministry announced.
There was no indication of any civilian impact in the attack late on Saturday and each participating jet returned to base without incident, the MoD added.
The British jets were assisted by a Voyager refuelling tanker.
Daesh - referred to as Daesh - imposed extremist governance over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This action underscores our UK leadership, and determination to stand shoulder to shoulder with allied nations, to stamp out any resurgence of Daesh and their violent and radical beliefs in the region," UK Defence Secretary the Defence Secretary remarked.
British military aircraft have carried out patrols over Syrian airspace to "prevent any attempted resurgence" of Islamic State subsequent to its military defeat at the climactic battle in Baghuz in the year 2019, the ministry said.
"I must thank the personnel of British forces who took part in this mission for their expertise and their bravery," Healey added. "They were part of a great many British troops on duty over the festive period. This action, to remove militants who endanger our safety, highlights how our armed forces are always on standby, all year round, keeping Britain secure at home and strong abroad."
Last December, the American forces conducted what it termed a "major assault" against Islamic State objectives in the country, after an attack killed two US troops and a civilian interpreter in Palmyra.
The United Nations reports Daesh still has roughly 5-7 thousand militants in Syria and Iraq.